Table 1.
PD candidate genes.
| Gene Name | Accession No. | Symbol | Screen | Position | Locus | |
|---|---|---|---|---|---|---|
| 1 | Tetraspanin 6 | NM_003270.2 | Tspan6 | Chung et al. | Xq22.1 | PARK 12 |
| 2 | ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast) | NM_001111112.1 | UBE2K | Chung et al. | 4p14 | PARK 5 |
| 3 | Ribosomal protein L11 | NM_000975.2 | RPL11 | Chung et al. | 1p36.1-p35 | PARK 6 & 7 |
| 4 | Ribosomal protein L36a | NM_021029.4 | RPL36A | Chung et al. | Xq22.1 | PARK 12 |
| 5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 | NM_003069.3 | SMARCA1 | Chung et al. | Xq25 | PARK 12 |
| 6 | MARCKS-like 1 | NM_023009.5 | MARCKSL1 | Chung et al. | 1p35.1 | PARK 6 |
| 7 | GTPase activating protein 24 | NM_001025616.2 | ARHGAP24 | Chung et al. | 4q21.23-4q21.3 | PARK 4 |
| 8 | F-box only protein 2 | NM_012168.4 | FBXO2 | Chung et al. | 1p36.22 | PARK 7 |
| 9 | T-complex-associated-testis-expressed 1-like | NM_006520.2 | DYNLT3 | Chung et al. | Xp21 | PARK 12 |
| 10 | Cyclin I | NM_006835.2 | CCNI | Chung et al. | 4q21.1 | PARK 4 |
| 11 | Solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 | NM_001152.4 | SLC25A5 | Chung et al. | Xq24-q26 | PARK 12 |
| 12 | Pyruvate dehydrogenase E1 alpha 1 | NM_000284.2 | PDHA1 | Greene et al. | Xp22.12 | PARK 12 |
| 13 | Ubiquitin carboxy-terminal hydrolase L1 PARK | NM_004181.4 | UCHL1 | Greene et al. | 4p14 | PARK 5 |
| 14 | G protein-coupled receptor, family C, group 5, member A | NM_003979.3 | GPRC5A | Grimm et al. | 12p13.1 | PARK 8 |
| 15 | Protein tyrosin phosphatase, receptor type, U | NM_005704.3 | PTPRU | Grimm et al. | 1p35.3 | PARK 6 |
| 16 | Klech-like 13 (drosophila) | NM_001168299.1 | KLHL13 | Grimm et al. | Xq24 | PARK 12 |
| 17 | Dehyrogenase/reductase (SDR family) member 3 | NM_004753.4 | DHRS3 | Grimm et al. | 1p36.22-1p36.21 | PARK 7 |
| 18 | NEL-like 2 (chicken) | NM_001145107.1 | NELL2 | Grimm et al. | 12q13.11-q13.12 | PARK 8 |
| 19 | Serin (or cysteine) peptidase inhibitor clade B, member 6a | NM_004568.4 | SERPINB6 | Grimm et al. | 6q25 | PARK 2 |
| 20 | Peripherin 1 | NM_006262.3 | PRPH | Grimm et al. | 12q12-q13 | PARK 8 |
The list of genes, with ISH-detectable expression in midbrain dopaminergic neurons, with cytogenetic locations, falling within PARK loci are shown. Numbers 1,4,5,9,11,12 and 16 are within PARK-12, an orphan PD locus and UCHL1 (13) is a known PD gene.