Figure 2.

Time period for LTP reversal by manipulations acting on adenosine A1 receptors is not prolonged in Fmr1-KO mice. Local applications of adenosine (200 μm; 4 min) or a 3 min train of 5 Hz stimulation (bar), two treatments known to reverse LTP when applied immediately after induction (TBS, arrow), had no lasting effects on potentiation when applied at 10 min after TBS in hippocampal slices (n = 4) prepared from Fmr1-KO mice. Both manipulations caused a transient depression of synaptic responses, as expected for stimulation of adenosine A1 receptors.