Table 2.

Articular cartilage explants were cultured with either IL1 (a) or NOC18 (b) for 48 hrs in either 20 or 1% O₂. ATP was extracted from the explants and measured. Data shown are means with 95% confidence intervals (lower limit, upper limit), N=18.

(a)
IL1 (ng/ml)	20% O2 ATP (ng/mg)	1% O2 ATP (ng/mg)	P
0	77 (63, 92)	59 (51, 67)	0.005
0.1	49 (39, 59)	46 (39, 53)	0.70
1	36 (28, 45)	35 (26, 44)	0.97
10	41 (33, 50)	37 (26, 47)	0.33
0 v 0.1, 1,10	<0.0001, <0.0001, <0.0001	0.05, 0.0004, 0.0005
0.1 v 1, 10	0.04, 0.26	0.09, 0.09
1 v 10	0.31	0.90

(b)
NOC18 (mM)	20% O2 ATP (ng/mg)	1% O2 ATP (ng/mg)	P
0	78 (58, 99)	40 (26, 53)	<0.0001
0.5	45 (32, 57)	24 (6, 42)	0.045
1	50 (33, 68)	18 (12, 25)	0.007
2	42 (31, 54)	19 (15, 24)	0.97
0 v 0.5, 1, 2	0.0004, 0.0004, <0.0001	0.11, 0.03, 0.03
0.5 v. 1, 2	0.89, 0.68	0.49, 0.48
1 v 2	0.61	0.97