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. Author manuscript; available in PMC: 2011 Sep 15.
Published in final edited form as: Toxicol Appl Pharmacol. 2010 Jul 15;247(3):169–178. doi: 10.1016/j.taap.2010.07.004

Figure 1.

Figure 1

Acetaminophen-induced liver injury in C57Bl/6 mice with or without caspase inhibitor. Animals were first treated with 300 mg/kg APAP and then two hours later with 10 mg/kg Z-VD-fmk or vehicle control. (A) Plasma ALT at 6 h and 24 h; (B) area of necrosis at 24 h. (C) Representative H&E-stained liver sections (x50 magnification) and immunohistochemistry for hepatic neutrophil accumulation (x200 magnification) are shown for controls and animals treated with APAP for 24 h. (D) Neutrophil numbers were quantified in 15 randomly selected high power fields (HPF; x400). Data represent means ± SE of n = 5 animals per group. *P<0.05 (compared to untreated controls).