Fig. 3.
Effect of recombinant mesotrypsin treatment on malignant growth of T4-2 cells in 3D culture. Cells were grown in Matrigel for 4 days in the absence (a) or presence (b) of 100-nM mesotrypsin. Scale bar, 100 µm. c Average colony size was significantly increased for mesotrypsin-treated versus untreated cells; data represented as mean ± SEM. * P < 0.0001 (unpaired t test)