TABLE 4.
Handling-Induced Convulsion Severity in Control and Ethanol Withdrawing Mice
| Strain | Control* | Ethanol-exposed | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Low Dose groups | High Dose groups | ||||||||
| AREA 25 | AREA 25 | ΔAREA 25 | ΔPEAK | Latency to Peak (hr)* |
AREA 25 | ΔAREA 25 | ΔPEAK | Latency to Peak (hr)* |
|
| 129S1 | 66.94 ± 2.49 | 99.43 ± 6.45 | 32.49 ± 6.45 | 2.69 ± 0.20 | 5.29 ± 0.29 | 102.00 ± 3.09 | 35.06 ± 3.09 | 2.67 ± 0.13 | 6.25 ± 0.70 |
| AKR | 2.00 ± 1.15 | 32.27 ± 7.85 | 30.27 ± 7.85 | 2.17 ± 0.31 | 4.91 ± 0.69 | ||||
| BALB | 54.13 ± 1.40 | 79.63 ± 4.72 | 25.51 ± 4.72 | 1.42 ± 0.18 | 3.13 ± 0.76 | ||||
| BTBR | 9.94 ± 3.82 | 64.54 ± 2.07 | 54.60 ± 2.07 | 2.27 ± 0.11 | 2.86 ± 0.63 | ||||
| C3H | 20.42 ± 10.14 | 5.30 ± 2.93 | 0 ** | 0.09 ± 0.40 | 3.40 ± 1.36 | ||||
| B6 | 0.00 ± 0.00 | 4.00 ± 1.77 | 4.00 ± 1.77 | 0.64 ± 0.20 | 2.69 ± 0.75 | ||||
| C57BR | 15.48 ± 2.48 | 52.41 ± 4.18 | 36.93 ± 4.18 | 2.78 ± 0.18 | 5.96 ± 0.52 | 64.67 ± 3.36 | 49.19 ± 3.36 | 3.41 ± 0.12 | 7.05 ± 0.50 |
| C57L | 6.60 ± 4.12 | 21.67 ± 6.70 | 15.07 ± 6.70 | 1.50 ± 0.27 | 5.44 ± 0.85 | ||||
| CBA | 32.56 ± 2.98 | 50.57 ± 3.16 | 18.01 ± 3.16 | 0.98 ± 0.07 | 6.14 ± 1.01 | 47.28 ± 3.31 | 14.72 ± 3.31 | 0.87 ± 0.11 | 5.78 ± 0.57 |
| CE | 0.40 ± 0.22 | 30.90 ± 3.59 | 30.50 ± 3.59 | 3.23 ± 0.33 | 6.40 ± 0.51 | 51.27 ± 6.13 | 50.87 ± 6.13 | 3.49 ± 0.48 | 10.13 ± 1.98 |
| D1 | 1.75 ± 1.05 | 42.21 ± 4.78 | 40.46 ± 4.78 | 2.88 ± 0.14 | 3.08 ± 0.42 | 63.17 ± 4.42 | 61.42 ± 4.42 | 3.29 ± 0.00 | 5.33 ± 1.20 |
| D2 | 41.00 ± 11.86 | 81.50 ± 6.71 | 40.50 ± 6.71 | 2.54 ± 0.16 | 6.64 ± 0.34 | ||||
| FVB | 17.33 ± 7.43 | 54.10 ± 8.12 | 36.77 ± 8.12 | 2.22 ± 0.32 | 4.20 ± 1.07 | 53.94 ± 4.34 | 36.61 ± 4.34 | 1.96 ± 0.09 | 5.57 ± 0.76 |
| PL | 37.44 ± 4.63 | 63.10 ± 4.41 | 25.66 ± 4.41 | 1.19 ± 0.19 | 4.00 ± 0.99 | 71.40 ± 7.42 | 33.96 ± 7.42 | 1.96 ± 0.24 | 6.60 ± 0.87 |
| SJL | 72.71 ± 0.55 | 75.86 ± 0.59 | 3.14 ± 0.59 | 1.00 ± 0.16 | 4.86 ± 0.51 | 87.75 ± 5.58 | 15.04 ± 5.58 | 1.57 ± 0.33 | 5.00 ± 1.08 |
| Means | 23.60 ± 2.21 | 51.12 ± 2.42 | 29.00 ± 1.81 | 1.97 ± 0.09 | 4.44 ± 0.22 | 64.05 ± 2.79 | 36.92 ± 2.50 | 2.50 ± 0.14 | 6.80 ± 0.41 |
For description of variables and their com putation, see text.
*
A “Peak” value is not shown for Control animals as HIC scores do not wax and wane in these groups. Nor is “Latency to Peak” calculated.
**
Withdrawal ΔAREA25 was slightly less than Control scores in the C3H/HeJ strain.