Table 1.
Clusters showing significant Group (Depressed, Nondepressed) × Time (Time 1, Time 2) interactions for the [Targets within Sad Blocks] minus [Targets within Neutral Blocks] contrast. The second-to-last column indicates results of two-tailed paired t-tests (i.e., Time 2 – Time 1) conducted on signal intensity t-values from MDD participants on clusters identified as significant from interaction tests. Negative t values denote a significant decrease in the MDD group after psychotherapy and positive t-values denote a significant increase in the MDD group after psychotherapy. The final column indicates the effect size of the paired t-test.
| Region | Brodmann’s Area | Size (mm3) | Z Max | Coordinates |
Effect of BATD: t (p) | Effect Size of BATD effect | ||
|---|---|---|---|---|---|---|---|---|
| X | Y | Z | ||||||
| Frontal Orbital Cortex (Right) | 48 | 2.1 | 20 | 16 | −14 | −2.14 (0.04) | 0.82 | |
| Frontal Pole | ||||||||
| Right | 10 | 40 | 2.05 | 24 | 72 | 0 | 1.36 (0.19) | 0.55 |
| Right | 56 | 2.29 | 28 | 56 | 6 | −2.69 (0.01) | 0.93 | |
| Right | 10 | 120 | 2.31 | 24 | 58 | 14 | −3.15 (0.00) | 1.03 |
| Left | 40 | 2.1 | −40 | 48 | 30 | 0.18 (0.86) | 0.06 | |
| Heschl’s Gyrus (Left) | 104 | 2.38 | −42 | −18 | 2 | −3.58 (0.005) | 1.36 | |
| Inferior Frontal Gyrus, pars triangularis (Right) | 152 | 2.41 | 48 | 26 | 0 | 2.38 (0.03) | 0.85 | |
| Occipital Pole (Left) | 40 | 2.39 | −32 | −96 | 26 | −2.22 (0.04) | 0.92 | |
| Pallidum (Right) | 96 | 2.52 | 18 | −6 | 4 | −1.84 (0.08) | 0.67 | |
| Paracingulate Gyrus (Left) | 9 | 64 | 2.17 | −8 | 48 | 14 | −4.44 (0.001) | 0.54 |
| Postcentral Gyrus | ||||||||
| Right | 88 | 2.1 | 22 | −42 | 54 | −3.41 (0.006) | 1.14 | |
| Right | 168 | 2.38 | 8 | −36 | 60 | −4.14 (0.001) | 1.41 | |
| Left | 40 | 40 | 2.08 | −48 | −30 | 60 | −2.35 (0.03) | 0.96 |
| Left | 136 | 2.4 | −36 | −30 | 66 | −2.06 (0.05) | 0.81 | |
| Precentral Gyrus | ||||||||
| Right | 264 | 2.27 | 26 | −12 | 64 | −2.41 (0.02) | 0.87 | |
| Right | 6 | 192 | 2.83 | 52 | −2 | 30 | −3.17 (0.009) | 1.17 |
| Left | 272 | 2.35 | −50 | 10 | 32 | 2.29 (0.03) | 0.82 | |
| Left | 168 | 2.4 | −28 | −20 | 48 | −1.72 (0.10) | 0.67 | |
| Left | 4 | 80 | 2.15 | −40 | −14 | 54 | −2.92 (0.01) | 1.09 |
| Temporal Gyrus (Superior, Posterior, Left) | 72 | 2.1 | −62 | −16 | 2 | −2.38 (0.03) | 0.99 | |
| Temporal Gyrus (Inferior, Posterior, Right) | 224 | 2.29 | 54 | −40 | −18 | −2.88 (0.01) | 0.98 | |
| Temporal Gyrus (Middle, Posterior, Left) | 21 | 72 | 2.33 | −70 | −30 | −8 | −2.54 (0.02) | 1.00 |
| Supramarginal Gyrus (Anteior, Right) | 64 | 2.24 | 36 | −38 | 36 | −2.30 (0.03) | 0.97 | |