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MAPK activation and histone modifications after acute alcohol treatment of rats
| 1 hr | 4 hr | |
|---|---|---|
| Injury | ||
| Apoptosis | ++ | ± |
| Steatosis | ± | + |
| Necrosis | ± | ++ |
| MAPK phosphorylation: Cytosolic | ||
| ERK1 | ++++ | ++ |
| ERK2 | ++++ | ++ |
| JNK1 | ++ | + |
| JNK2 | ++ | + |
| p38 MAPK | ++ | + |
| MAPK phosphorylation: Nuclear | ||
| ERK1 | ++++ | ++ |
| ERK2 | ++++ | ++ |
| JNK1 | ++ | + |
| JNK2 | ++ | + |
| p38 MAPK | + | ± |
| Epigenetic histone modifications | ||
| H3 Ser 10 phosphorylation | ++ | ± |
| H3 Ser 28 phosphorylation | ++ | ± |
| H3 K9 acetylation | + | ++ |
