Table 1.
Characteristics of study participants, overall and stratified by HIV co-infection status
| Total (N=1,266) |
HIV-negative (N=795) |
HIV-positive (N= 471) |
P-value* | |
|---|---|---|---|---|
| N (%) | ||||
| Age at enrollment (yr) | ||||
| Median (range) | 36 (13-88) | 37 (13-82) | 35 (17-88) | |
| 13-26 | 325 (25.7) | 241 (30.3) | 84 (17.8) | <0.0001 |
| 27-35 | 292 (23.0) | 135 (17.0) | 157 (33.3) | |
| 36-46 | 343 (27.1) | 181 (22.8) | 162 (34.4) | |
| 47-88 | 306 (24.2) | 238 (29.9) | 68 (14.5) | |
| Race | 0.26 | |||
| White | 1,002 (79.1) | 637 (80.1) | 365 (77.5) | |
| Black | 153 (12.1) | 85 (10.7) | 68 (14.4) | |
| Hispanic | 61 (4.8) | 41 (5.2) | 20 (4.2) | |
| Others | 50 (4.0) | 32 (4.0) | 18 (3.8) | |
| Gender | <0.0001** | |||
| Male | 1,210 (95.6) | 741 (93.2) | 469 (99.6) | |
| Female | 56 (4.4) | 54 (6.8) | 2 (0.4) | |
| Hemophilia Type | <0.0001 | |||
| A | 950 (75.0) | 539 (67.8) | 411 (87.3) | |
| B | 223 (17.6) | 166 (20.9) | 57 (12.1) | |
| Others | 93 (7.3) | 90 (11.3) | 3 (0.7) | |
| Hemophilia severity | <0.0001 | |||
| Severe | 803 (63.4) | 434 (54.6) | 369 (78.3) | |
| Moderate | 218 (17.2) | 151 (19.0) | 67 (14.3) | |
| Mild | 242 (19.1) | 207 (26.0) | 35 (7.4) | |
| Missing | 3 (0.3) | 3 (0.4) | 0 | |
| HCV genotype | <0.0001 | |||
| 1 | 697 (55.0) | 418 (52.6) | 279 (59.3) | |
| 2 or 3 | 219 (17.3) | 131(16.5) | 88 (18.7) | |
| Others | 57 (4.5) | 29 (3.6) | 28 (5.9) | |
| Missing | 293 (23.2) | 217 (27.3) | 76 (16.1) | |
| HBV co-infection | <0.0001 | |||
| Uninfected | 487 (38.5) | 371(46.7) | 116 (24.6) | |
| Resolved infection | 422 (33.3) | 218 (27.4) | 204 (43.4) | |
| Chronic infection | 34 (2.7) | 17 (2.1) | 17 (3.6) | |
| Missing | 323 (25.5) | 189 (23.8) | 134 (28.4) | |
| Current Antiretroviral therapy | ||||
| No | N/A | 108 (24.4) | ||
| Combined | 246 (55.5) | |||
| Other | 89 (20.1) | |||
| CD4 counts (cells/μL) | ||||
| >500 | N/A | 129 (30.7) | ||
| 200-500 | 208 (49.5) | |||
| <200 | 83 (19.8) | |||
| HCV load (copies/ml) | ||||
| Median | 3.2 ×106 | 2.7×106 | 4.7×106 | 0.0006 |
| (range) | (210-162.9×106) | (215-162.9×106) | (215-132.9×106) | |
| ≤ 2×106 | 483 (38.1) | 332 (41.7) | 151 (32.1) | |
| > 2×106 | 783 (61.8) | 463 (58.2) | 320 (67.9) | |
*
chi-square test for the difference between HIV-negative and positive participants
**
Fisher-exact test