Figure 1.

Sub-millimetre scale epileptiform activity in human partial epilepsy includes microseizures (µSz), microperiodic epileptiform discharge (µPED) and high-frequency oscillations (HFO). Panels A1–A5 each show representative examples of interictal intracranial EEG recorded (150 s) from a hybrid subdural grid (B) containing clinical macro- and microelectrode arrays in a patient with partial epilepsy. Microseizures (red), microperiodic epileptiform discharges (green) and high-frequency oscillations (blue) are highlighted in panels A1–5, and examples shown on an expanded scale in panels C1–5. The microseizures (C1,3,4), microperiodic epileptiform discharges (C2) and high-frequency oscillations (C5) shown here are isolated to single microelectrodes and not detected on adjacent microelectrodes or macroelectrodes. Additional details and expanded views are in the Supplementary Material.