. Author manuscript; available in PMC: 2010 Oct 1.

Published in final edited form as: Org Biomol Chem. 2009 Aug 7;7(20):4163–4165. doi: 10.1039/b911483a

Table 1.

Antimalarial activity and toxicity of selected quinoline methanols.²⁰ The units are ng/mL for IC₅₀, IC₉₀ and LC₅₀ data. The selectivity index (SI) is the ratio of the LC₅₀ against RAW macrophages relative to the PfW2 IC₅₀

Analog	Pf W2		Pf D6		Pf C235		Pf C2A		RAW LC₅₀	SI
Analog	IC₅₀	IC₉₀	IC₅₀	IC₉₀	IC₅₀	IC₉₀	IC₅₀	IC₉₀	RAW LC₅₀	SI
1	2.5	9.8	8.0	20	18	63	22	87	5064	2026
2	3.3	11	9.2	33	9.8	39	14	52	13740	4164
3	3.3	13	12	45	10	47	16	80	ND	ND
10	5.0	16	17	67	53	140	21	130	ND	ND
11	3.0	17	12	37	30	86	13	60	ND	ND