Table 3.
Linkage results for the total number of Autism Spectrum Disorder (ASD) Symptoms and the 3 ASD symptom domains
SCQ scale | Chromosome | Position (cM)a | Locationb | Marker | LOD | No. of markersc |
---|---|---|---|---|---|---|
Total | 12 | 167.2 | 12q24.3 | rs1487602 | 0.772 | 1 |
Social | . | . | . | . | . | |
Communication | 15 | 78.88 | 15q24.1 | rs896588 | 2.278 | 2 (2.1) |
Restricted & repetitive | 7 | 177.27 | 7q36.2 | rs1657290 | 1.689 | 2 (0.6) |
16 | 11.67 | 16p13.3 | rs859302 | 1.992 | 2 (2.3) | |
18 | 2.21 | 18p11.32 | rs1557299 | 3.216 | 6 (8.1) | |
Conners added to covariates | ||||||
Total | 12 | 167.2 | 12q24.3 | rs1487602 | 1.86 | 1 |
Social | . | . | . | . | . | |
Communication | 15 | 76.79 | 15q24.1 | rs1348318 | 1.692 | 1 |
Restricted & repetitive | 7 | 176.66 | 7q36.2 | rs306278 | 2.311 | 3 (2.0) |
16 | 11.67 | 16p13.3 | rs859302 | 2.105 | 3 (4.5) | |
18 | 4.64 | 18p11.32 | rs1371264 | 2.77 | 7 (10.5) |
Note. LOD=Logarithm of the odds; SCQ=Social Communication Questionnaire.
DeCODE Genetic map position
Most likely cytogenic location
Number of consecutive SNP markers with LODs above thresholds for suggestive linkage and (in brackets) the genetic distance they span.