Table 2.

Critical appraisal.

Study	Study design	Relevance			Blinding			Missing Data		Internal validity					Results
		Domain	Determinant	Outcome	Determinant	Outcome	Follow-up (months)	Drop-out (%)	Loss-to-follow-up (%)	Selectionbias	Informationbias	External Validity	Standardisation	Level of Evidence [8]	Effect measures	Precision measures
Bork et al. [6]	Retrospective	Women in the childbearing years with stage I malignant melanoma.	Pregnancy after primary therapy.	Recurrence & Disease-free survival.	n.a.	n.a.	n.a.	?	?	n.a.	n.a.	−	−	3	None	None
Reintgen et al. [9]	Retrospective case/control	Women in the childbearing years treated for stage I primary cutaneous melanoma.	Pregnancy within 5 years of diagnosis.	Disease-free interval (10 years).	n.a.	n.a.	n.a.	None	None	n.a.	n.a.	+	±	2B	χ 2	P
Shaw et al. [5]	Retrospective	Women with malignant melanoma.	Pregnancy after diagnosis.	Local recurrence.	n.a.	n.a.	n.a.	?	?	n.a.	n.a.	−	?	3	None	None
MacKie et al. [10]	Retrospective cohort	Women in the reproductive years treated for stage I primary melanoma.	First pregnancy after diagnosis.	Disease-free survival (20 years).	n.a.	n.a.	n.a.	None	None	n.a.	n.a.	+	±	2B	RR	p&CI

+: Good, ±: Moderate, −: Poor, ?: Unknown, n.a.: Not Applicable, RR: Relative risk, CI: Confidence Interval, P: P-value.