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. Author manuscript; available in PMC: 2010 Aug 29.
Published in final edited form as: J Am Chem Soc. 2008 Mar 6;130(12):3900–3914. doi: 10.1021/ja0772041

Table 3.

NOS Enzyme Assay Results for the Lead Compounds

compd Ki (μM)
 selectivity
nNOS eNOS iNOS n/e n/i
(±)-4 0.388 434.5 58.4 1114 150
(±)-5 3.17 88.5 166.2 28 53
(±)-6 9.44 366.6 143.1 39 15
(±)-7 1.59 403.5 51.9 254 33
(±)-8 47.94 121.6 609.4 3 13
(±)-9 305.0 849.2 2523 3 8
(±)-10 8.76 866.2 77.4 99 9
(±)-11 13.28 85.2 143.8 6 11
(±)-12 28.54 683.7 233.8 24 8
(±)-13 2.34 242.3 71.5 104 31
(±)-14 13.98 44.7 60.1 3 4
(±)-15 190.3 677.7 1750 4 9