Table 4.
Multivariate analyses comparing TRM, progression/relapse, PFS and OS for unrelated donor NST/RIC HCT for relapsed/refractory HD.
| Variables: | N | Relative Risk (95% CI) |
P-value |
|---|---|---|---|
| TRM: | |||
| Karnofsky score pre-transplant | |||
| ≥90% | 79 | 1.00 | |
| <90% | 37 | 3.05 (1.58 - 5.87) | <0.001 |
| Extranodal involvement | |||
| No | 71 | 1.00 | |
| Yes | 68 | 2.36 (1.26 - 4.41) | 0.007 |
| Progression/Relapse: | N/A | ||
| No significant variables | |||
| PFS: | |||
| Karnofsky score pre-transplant | |||
| ≥90% | 79 | 1.00 | |
| <90% | 37 | 2.19 (1.42 - 3.39) | <0.001 |
| Extranodal involvement | |||
| No | 71 | 1.00 | |
| Yes | 68 | 1.73 (1.17 - 2.55) | 0.006 |
| OS: | |||
| Karnofsky score pre-transplant | |||
| ≥90% | 74 | 1.00 | |
| <90% | 36 | 2.33 (1.45 - 3.75) | <0.001 |
| Extranodal involvement | |||
| No | 65 | 1.00 | |
| Yes | 69 | 2.11 (1.34 - 3.31) | 0.001 |
| LDH concentration | |||
| Normal | 96 | 1.00 | |
| Abnormal | 38 | 1.86 (1.18 - 2.93) | 0.008 |
Abbreviations: CI = confidence interval, NA=not applicable.