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. Author manuscript; available in PMC: 2010 Aug 30.
Published in final edited form as: Genes Chromosomes Cancer. 2009 Jan;48(1):83–97. doi: 10.1002/gcc.20620

Figure 1. Hierarchical clustering of the differentially expressed transcripts in all of the biological replicate samples.

Figure 1

Two-way hierarchical clustering using Ward’s Minimum Variance as the heuristic criteria and Euclidean distance as the similarity metric was performed on all 4 samples using the z-score transformed expression values for the 2,339 transcripts that were identified as differentially expressed (fold-change > 5, log ratio p-value < 0.001) when the two groups were compared to each other (984 genes displayed increased expression, 1,355 displayed decreased expression in response to 5-azadC/TSA). The degree of relatedness between each sample is represented by the dendrogram (hierarchical tree) presented in this figure, wherein the height of each branch represents the distance between the 2 objects being connected. The relationship between the color intensity and the expression level is illustrated by the color bar.