Table 1.
bNOS protection against a wide spectrum of antimicrobials. A representative list of chemicals from the Phenotype MicroArray screen that preferentially inhibit the growth of nos-deficient B. subtilis. Negative numbers indicate the relative growth inhibition (as provided by Biolog, fig. S1) of the Δnos strain compared to that of the wt strain.
| Δnos inhibition | Chemical | Proposed biological effect/chemical type |
|---|---|---|
| −76 | 5-Chloro-7-iodo-8-hydroxyquinoline | DNA intercalator/quinolone |
| −62 | 8-Hydroxyquinoline | DNA intercalator/quinolone |
| −67 | 8-Hydroxy-5-nitroquinoline | DNA intercalator/quinolone |
| −80 | Novobiocin | DNA intercalator/quinolone |
| −209 | Acriflavine | DNA intercalator/acridine |
| −44 | 9-Aminoacridine | DNA intercalator/acridine |
| −109 | Prochlorperazine | DNA intercalator/phenothiazine |
| −77 | Chlorpromazine | DNA intercalator/phenothiazine |
| −45 | Prochlorperazine | DNA intercalator/phenothiazine |
| −68 | Penimepicycline | Protein synthesis/tetracycline |
| −64 | Sisomicin | Protein synthesis/aminoglycoside |
| −40 | Gentamicin | Protein synthesis/aminoglycoside |
| −252 | Cephaloridine | Cell wall metabolism/cephalosporin |
| −124 | 7-Aminocephalosporanic acid | Cell wall metabolism/cephalosporin |
| −110 | Cefotaxime | Cell wall metabolism/cephalosporin |
| −173 | Cefuroxime | Cell wall metabolism/cephalosporin |
| −114 | Ampicillin | Cell wall metabolism/lactam |
| −79 | Moxalactam | Cell wall metabolism/lactam |
| −78 | 6-Aminopenicillanic acid | Cell wall metabolism/lactam |
| −73 | Amoxicillin | Cell wall metabolism/lactam |
| −39 | Azlocillin | Cell wall metabolism/lactam |