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. Author manuscript; available in PMC: 2011 Aug 6.
Published in final edited form as: Org Lett. 2010 Aug 6;12(15):3300–3303. doi: 10.1021/ol100923d

Figure 3.

Figure 3

Hoechst-IR can image tissue necrosis in vivo caused by LPS-GalN induced sepsis. (A) (i) Representative fluorescent image of mouse treated with an i.p. injection of LPS (2.5 μg/kg) and GalN (700 mg/kg), followed by an i.v. injection of Hoechst-IR (5 mg/kg), (ii) representative fluorescent image of mouse treated with an intraperitoneal injection of saline, followed by an i.v. injection of Hoechst-IR (5 mg/kg). (B) Quantification of Hoechst-IR fluorescence intensities of mice treated with LPS-GalN and saline. Mice treated with LPS-GalN have a 3–4 fold increase in fluorescence over mice treated with saline (*P < 0.05, n = 5).