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. Author manuscript; available in PMC: 2010 Aug 30.

Published in final edited form as: Cardiol Clin. 2009 May;27(2):291–Contents. doi: 10.1016/j.ccl.2008.12.004

A. Effects of simvastatin on 18FDG uptake in atherosclerotic plaque inflammation. Representative 18FDG-PET images at baseline and after 3 months of treatment (post-treatment) with dietary management alone (diet) or simvastatin. (Top) Dietary management alone had no effect on 18FDG uptakes (arrows) in the aortic arch and the carotid arteries. (Middle) 18F-fluorodeoxyglucose uptakes were attenuated by simvastatin treatment. (Bottom) The co-registered images of 18FDG-PET and CT clearly show that the plaque 18FDG uptakes (arrowheads) disappeared after 3-month treatment with simvastatin. 10B. Correlations of changes in plaque 18F-fluorodeoxyglucose uptakes (ΔSUV) with alterations in HDL cholesterol (ΔHDL, mg/dl) and LDL cholesterol (ΔLDL, mg/dl) after 3-month treatment with dietary management alone (diet) or simvastatin. ΔSUV had a significant correlation only with ΔHDL in the statin group (LDL) cholesterol (A) and high-density lipoprotein (HDL) cholesterol. Reproduced with permission from Tahara N, Kai H, Ishibashi M, et al. Simvastatin attenuates plaque inflammation: evaluation by fluorodeoxyglucose positron emission tomography. J Am Coll Cardiol. Nov 7 2006;48(9):1825–1831.

A. Effects of simvastatin on 18FDG uptake in atherosclerotic plaque inflammation. Representative 18FDG-PET images at baseline and after 3 months of treatment (post-treatment) with dietary management alone (diet) or simvastatin. (Top) Dietary management alone had no effect on 18FDG uptakes (arrows) in the aortic arch and the carotid arteries. (Middle) 18F-fluorodeoxyglucose uptakes were attenuated by simvastatin treatment. (Bottom) The co-registered images of 18FDG-PET and CT clearly show that the plaque 18FDG uptakes (arrowheads) disappeared after 3-month treatment with simvastatin. 10B. Correlations of changes in plaque 18F-fluorodeoxyglucose uptakes (ΔSUV) with alterations in HDL cholesterol (ΔHDL, mg/dl) and LDL cholesterol (ΔLDL, mg/dl) after 3-month treatment with dietary management alone (diet) or simvastatin. ΔSUV had a significant correlation only with ΔHDL in the statin group (LDL) cholesterol (A) and high-density lipoprotein (HDL) cholesterol. Reproduced with permission from Tahara N, Kai H, Ishibashi M, et al. Simvastatin attenuates plaque inflammation: evaluation by fluorodeoxyglucose positron emission tomography. J Am Coll Cardiol. Nov 7 2006;48(9):1825–1831.