Measurements of overall myocardial glucose uptake (MGU), glycolysis, glucose oxidation and glycogen synthesis for normal volunteers (NV), type-1 diabetic patients studied under baseline metabolic conditions (DM1) and diabetic patients studied during hyperinsulinemic-euglycemic clamp (DM1-C) both at rest (open bars) and during dobutamine (closed bars). Reproduced with permission from Herrero P, McGill JB, Lesniak D, et al. PET detection of the impact of dobutamine on myocardial glucose metabolism in women with type 1 diabetes mellitus. J Nucl Cardiol. November-December 2008;15(6):598–604.