Figure 8. Prkar1a heterozygosity instructs a widespread transcriptional shift during spontaneous tumorigenesis.

(A) Principle component analysis (PCA) and (B) hierarchical clustering of PKA⁺, PKA^–, and Prkar1a^ΔOB/+/MOTO⁺ tumors, using a 508 gene-training signature. All Prkar1a^ΔOB/+/MOTO⁺ mice were 3.4–4.7 weeks of age.