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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Cancer J. 2010 Jul–Aug;16(4):374–381. doi: 10.1097/PPO.0b013e3181eb33a6

Figure 2. Examples of cellular artificial APC systems.

Figure 2

A) K562 erythroleukemia cells can be transduced with the human Fcγ receptor, CD64, to allow Fc binding of antibodies to CD3 and CD28. Other costimulatory signals could be delivered alone or in concert with CD28 by adding specific antibodies.

B) K562 erythroleukemia cells can be transduced with HLA-A*0201 and a TAA. Proteosomal processing of the expressed TAA results in presentation of TAA-derived peptide antigens in conjunction with the transduced HLA-A*0201. Costimulation can be provided by transduction with CD80 (or other costimulatory molecules as desired).