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FORMULATION AND EVALUATION OF PARACETAMOL TABLETS
| Ingredients/Evaluation | Batch code |
||
|---|---|---|---|
| AG1 | AG2 | AG3 | |
| Paracetamol (mg) | 500 | 500 | 500 |
| PEG 6000 (mg) | 100 | 80 | 50 |
| Crospovidone (%)a | 6 | 6 | 5 |
| Cab-O-Sil (%)b | 0.5 | 0.5 | 0.5 |
| Magnesium stearate (%)b | 0.5 | 0.5 | 0.5 |
| MCC granules (mg) | 110 | 110 | 110 |
| Friability (%) | 0.3 | 0.5 | 2.0 |
| Crushing strength (N) | 55 | 45 | 25 |
| Disintegration time (min) | 11 | 8 | 2 |
Selected on basis of paracetamol;
selected on basis of total mass of paracetamol, PEG 6000, crospovidone and MCC granules
