TABLE 2.
FORMULATION AND EVALUATION OF PARACETAMOL TABLETS ACCORDING TO 23 FULL FACTORIAL DESIGN
| Ingredients/Results | Batch code |
|||||||
|---|---|---|---|---|---|---|---|---|
| AF1 | AF2 | AF3 | AF4 | AF5 | AF6 | AF7 | AF8 | |
| Paracetamol (mg) | 500 | 500 | 500 | 500 | 500 | 500 | 500 | 500 |
| PEG 6000 (mg) | 75 | 75 | 75 | 75 | 125 | 125 | 125 | 125 |
| Crospovidonea (%) | 4 | 6 | 4 | 6 | 4 | 6 | 4 | 6 |
| Cab-O-Sil (%)b | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 |
| Magnesium stearate (%)b | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 |
| MCC granules (mg) | 62.5 | 62.5 | 110 | 110 | 62.5 | 62.5 | 110 | 110 |
| Friability (%) | 0.8 | 0.6 | 0.9 | 0.8 | 0.2 | 0.4 | 0.4 | 0.6 |
| Crushing strength (N) | 35 | 75 | 60 | 42.5 | 65.5 | 70 | 65 | 71.3 |
| Disintegration time (min) | 23 | 27 | 13 | 7 | 29 | 25 | 20 | 16 |
a
Selected on basis of paracetamol;
b
selected on basis of total mass of paracetamol, PEG 6000, crospovidone and MCC granules