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Hybrid tumour modelling: evolution of a tumour spheroid in the absence of the outer gel from the study by Othmer and co-workers [317]. Necrosis is represented by the inner (white) region; it is enclosed by the continuum quiescent region and the outer cell-based region (space unit = 10 μm). Reprinted with permission from Kim et al Math. Models Methods Appl. Sci. 17 1790. Copyright © (2007) World Scientific.
