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. Author manuscript; available in PMC: 2010 Aug 30.
Published in final edited form as: Biol Psychiatry. 2004 Nov 1;56(9):640–650. doi: 10.1016/j.biopsych.2004.08.022

Figure 3.

Figure 3

Neuronal (A) and glial (B) density in the hippocampus of control subjects and subjects with major depressive disorder (MDD). Pyramidal neurons were quantified in hippocampal fields CA1–CA3, and granule cells were quantified in the granule cell layer of the dentate gyrus (DGgr) of 21 control subjects and CA3 and dentate gyrus (DGgr) from 19 depressed subjects. Data in CA1 and CA2 are presented from 18 depressed subjects. Values are least squares adjusted means ± SE. (A) There is a significant effect of diagnosis on pyramidal neuron density in all CA subfields (*p < .0001) and granule cell density in the dentate gyrus (**p = .0004). Pyramidal neuron density is increased by 35%–36% in CA subfields, and granule cell density is increased in the dentate gyrus by 37%. (B) There is a significant effect of diagnosis on glial cell density in all CA pyramidal neuron subfields (*p < .0001) and glial cell density in the granule cell layer of the dentate gyrus (**p = .0007). Glial cell density is increased by 28%–31% in the CA pyramidal neuron subfields and glial cell density is increased in the granule cell layer of the dentate gyrus by 30%.