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. Author manuscript; available in PMC: 2010 Aug 30.
Published in final edited form as: Mol Cancer Ther. 2008 Feb;7(2):286–296. doi: 10.1158/1535-7163.MCT-07-0483

Fig. 4.

Fig. 4

Fig. 4

Fig. 4

Fig. 4

Effects of MSLN on pancreatic cancer growth in the xenograft nude mouse model. A. Subcutaneous tumor volume of MIA-MSLN cells. MIA-MSLN or MIA-V cells (2 × 106) were subcutaneously inoculated into nude mice (10 mice per treatment group). Tumor size was measured weekly for 4 weeks. **p < 0.01. B. Subcutaneous tumor volume of BxPC-siMSLN cells. 2 × 106 BxPC-siMSLN cells were injected into the right flank of nude mice (eight per treatment group). Tumor size was measured weekly for 6 weeks. **p < 0.01. C. Orthotopic tumor volume of MIA-MSLN cells. 2×106 MIA-MSLN or MIA-V cells were implanted into the body of pancreases in nude mice (10 in each group). The mice were euthanized at different times. Orthotopic tumor volume was measured. Tumor volume in mice given MIA-MSLN inoculation was significantly higher than that in mice given MIA-V inoculation (**p < 0.01). D. Survival rate of nude mice with orthotopically inoculated tumors. 2 × 106 MIA-MSLN or MIAV cells were implanted into the body of pancreases in nude mice (10 in each group). Death was recorded up to 4 weeks after tumor inoculation. Survival of mice with MIA-MSLN inoculations was substantially lower than that of mice with MIA-V inoculations (p<0.00001).