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. 2010 Jun 15;42(3):469–479. doi: 10.1152/physiolgenomics.00070.2010

Fig. 3.

Fig. 3.

Hindlimb collateral number before ligation (“baseline”) and collateral remodeling after FAL vary among strains. A: X-ray arteriogram for determination of collateral number (vessels intersecting red dotted lines). D: native collaterals in the posterior gracilis muscle stained with cyano-Masson's elastin for determination of collateral diameter. B, C, E, and F: baseline (native) and % increase in collateral number and diameter 21 days after FAL for the 6 strains confirm the conclusions suggested by the perfusion data given in Figs. 1, 2, and 4. That is, native collateral number in hindlimb skeletal muscle follows the pattern C57BL/6 > BALB/c > A/J, collateral remodeling follows the pattern A/J > C57BL/6 > BALB/c, a locus(loci) on Chr 7 has a major effect on baseline differences in collateral number between A/J and C57BL/6 with Chr 17 also contributing, loci on Chr 7 and an additional chromosome(s) influence differences in remodeling between A/J and C57BL/6, and the C57BL/6 genome is dominant in the CXB-F1 population for the traits shown in B, C, E, and F. Values are means ± SE.