Figure 4. Effect of JNK-deficiency on Trp53^−/− mouse survival.

A) Kaplan-Meier analysis of the tumor-free survival of wild-type (WT), Jnk1 ^−/−, Jnk2 ^−/−, Trp53 ^−/−, Jnk1 ^−/− Trp53 ^−/−, and Jnk2 ^−/− Trp53 ^−/− mice is presented. No statistically significant differences between Trp53 ^−/−, Jnk1 ^−/− Trp53 ^−/−, and Jnk2 ^−/− Trp53 ^−/− mice were detected (Log-rank test, p>0.05). The data represent groups of 44–62 mice. These groups include equal numbers of male and female mice. B) The spectrum of tumors detected in Trp53 ^−/−, Jnk1 ^−/− Trp53 ^−/−, and Jnk2 ^−/− Trp53 ^−/− mice following euthanasia is presented. No statistically significant differences in the tumor profiles between genotypes were detected using Fisher's exact test.