Fig. 7.
Immunohistochemical analysis of cell division (A, B, and E) and apoptosis (C, D, and F) in H358 microtumors in SCID mouse lungs treated with either PBS (A and C) or IFN-β-hUCMSCs (B and D). Xenografts were collected as described in the Figure 5 legend. Cell division in H358 lung adenocarcinoma xenografts was analyzed by evaluating the area of anti-Ki-67 positive cells (panels A and B). Apoptosis was analyzed by counting TUNEL positive cells (panel C and D). The average Ki-67 positive area (E) and TUNEL positive cells (F) were determined by analyzing ten tumor areas in each treatment group and expressed in the bar graph. *, p < 0.05 as compared to the level of PBS-treated control.