Table 1.
Genetic and epigenetic silencing of CHFR.
| ID | Fold Relative DNA copy numbers |
% Methylation | Fold Relative mRNA expression |
|
|---|---|---|---|---|
| methylation ≤ 20% | 615T | 0.02 | 6.96 | 0 |
| 228T | 0.03 | 1.93 | 0.05 | |
| 533T | 0.05 | 19.61 | 0.43 | |
| 158T | 0.22 | 9.68 | 0.34 | |
| 602T | 0.25 | 4.18 | 0.25 | |
| 602T | 0.31 | 4.18 | 0.58 | |
| 658T | 0.47 | 4.39 | 0.17 | |
| 149T | 0.6 | 1.39 | 0.69 | |
| 101T | 0.68 | 4.14 | 0.02 | |
|
| ||||
| methylation ≥ 20% | 409T | 0.57 | 42 | 0.01 |
| 195T | 0.35 | 38 | 0.07 | |
| 460T | 0.54 | 64 | 0.1 | |
| 299T | 0.07 | 58 | 0.11 | |
| 70T | 0.43 | 35 | 0.24 | |
| 438T | 0.06 | 41 | 0.54 | |
| 1653T | 0.04 | 32 | 0.16 | |
The upper section demonstrates cases that had mRNA down-regulation of CHFR in absence of promoter DNA methylation (≤20%). The lower section shows a combination of DNA methylation (≥20%) and loss of DNA copy numbers.