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PAX3-FKHR transgene expression correlates with neural tube dysmorphology. (A) Whole-mount in situ hybridization shows transgene expression in the dorsal neural tube and lateral dermomyotome. Expression of mouse Pax3 in an entire control embryo is shown for comparison. With the exception of MP3–5, expression in the developing head region was absent in the other lines. (B) H&E-stained sections of E11.5 neural tubes taken at the level of the hindlimb buds.
