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. 2001 Feb 13;98(4):1589–1594. doi: 10.1073/pnas.98.4.1589

Figure 6.

Figure 6

Negative influence of PAX3-FKHR on Pax3 activity. Kaplan–Meier survival plots of offspring resulting from HA21 × Splotch matings show that HA21 Tg+Sp± mice had a significantly reduced lifespan (A). The survival of Tg−Sp+/+ (row 2, n = 20), Tg−Sp± (row 1, n = 20), Tg+Sp+/+ (row 3, n = 23), and Tg+Sp± (row 4, n = 9) mice was monitored over the course of 120 days. PAX3 and PAX3-FKHR compete for transcriptional activity (B). When increasing amounts of PAX3 were added (50 ng, 100 ng, and 1 μg), PAX3-FKHR transactivation of PRS-9 was blocked to the levels of PAX3 alone. The activity from PAX3-FKHR alone was arbitrarily set at 100%.