Table 3.

Multivariate analysis of risk factors associated with having a severe (grade 3) or life-threatening (grade 4) health condition

Risk Factors	Model 1 Odds ratio (95% CI)	P-Value	Model 2 Odds ratio (95% CI)	P-Value
Gender
Male	1.00		1.00
Female	1.18 (0.79–1.77)	0.41	1.15 (0.76–1.73)	0.51
Age
Age at HCT	0.88 (0.81–0.96)	0.004	0.88 (0.80–0.96)	0.003
Age at study participation	1.17 (1.07–1.27)	0.0007	1.17 (1.07–1.27)	0.0008
Ethnicity
Non-Hispanic white	1.00		1.00
Hispanic	0.47 (0.27–0.83)	0.009	0.56 (0.29–1.08)	0.08
Diagnosis
SAA/MM/Other	1.00		1.00
Chronic myeloid leukemia	0.70 (0.30–1.65)	0.41	0.65 (0.27–1.54)	0.32
Acute leukemia	0.95 (0.44–2.08)	0.90	0.93 (0.42–2.06)	0.85
Lymphoma	1.02 (0.47–2.23)	0.95	0.94 (0.43–2.07)	0.88
Type of transplant
Autologous	1.00		1.00
Allogeneic, no active chronic GvHD	1.13 (0.63–2.06)	0.68	1.17 (0.64–2.15)	0.61
Allogeneic, active chronic GvHD	4.01 (1.97–8.14)	0.001	3.99 (1.94–8.24)	0.002
Conditioning regimen
Chemotherapy	1.00		1.00
Chemotherapy + TBI	1.81 (0.99–3.29)	0.05	1.94 (1.06–3.56)	0.03
Year of transplant
≤1990	1.00		1.00
1991 to 1995	1.21 (0.54–2.67)	0.64	1.23 (0.55–2.77)	0.61
≥1996	0.91 (0.31–2.72)	0.87	0.92 (0.30–2.81)	0.89
Insurance status
Uninsured			1.00
Insured			3.46 (1.50–8.01)	0.004
Education
Less than high school			1.00
Completed high school			0.98 (0.45–2.12)	0.95

Abbreviations: HCT – hematopoietic cell transplantation; GvHD –graft versus host disease; TBI – total body irradiation; CI – confidence interval.