Table 4.

Brain levels (mean ± standard deviation) of estrogens and androgens in male cases neuropathologically characterized as normal, mild neuropathology, and AD, and grouped by age: all cases (50–97 years), 60–79 years, and ≥80 years.

	Cond.	Sample size	Age, years	PMI, hours	T, ng/g WT	DHT, ng/g WT	E1, ng/g WT	E2, ng/g WT
All cases	NOR	17	77.1 ± 2.3	5.2 ± 0.7	0.77 ± 0.09	0.15 ± 0.01	0.39 ± 0.15	0.09 ± 0.03
	MNC	17	79.5 ± 1.9	4.9 ± 0.7	0.57 ± 0.09	0.15 ± 0.02	0.57 ± 0.16	0.11 ± 0.03
	AD	33	76.6 ± 1.4	3.8 ± 0.6	0.5 ± 0.07	0.13 ± 0.01	0.81 ± 0.11	0.12 ± 0.02
60−79 y	NOR	7	71.1 ± 2.2	5.8 ± 1.1	1.03 ± 0.15	0.19 ± 0.03	0.44 ± 0.18	0.12 ± 0.03
	MNC	7	71.9 ± 2.2	5.5 ± 1.3	0.55 ± 0.2*	0.12 ± 0.03	0.45 ± 0.2	0.09 ± 0.04
	AD	22	73.0 ± 1.2	3.4 ± 0.9	0.54 ± 0.1*	0.14 ± 0.01	0.9 ± 0.1	0.13 ± 0.02
≥80 y	NOR	8	87.2 ± 1.6	3.9 ± 1.0	0.29 ± 0.18	0.08 ± 0.04	0.40 ± 0.21	0.07 ± 0.04
	MNC	10	85.0 ± 1.2	4.1 ± 0.7	0.42 ± 0.15	0.14 ± 0.03	0.35 ± 0.17	0.07 ± 0.07
	AD	11	84.6 ± 1.2	4.4 ± 0.8	0.67 ± 0.15	0.15 ± 0.03	0.61 ± 0.17	0.12 ± 0.03

^*p < 0.05 relative to age-matched neuropathologically normal (NOR) group