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. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: Arch Biochem Biophys. 2010 May 5;501(1):79–90. doi: 10.1016/j.abb.2010.05.003

Figure 3. Role of FOXO and SIRT1 in cell functions.

Figure 3

FOXO transcription factor is shown to regulate cellular signaling involved in DNA repair, cell cycle, oxidative stress, and apoptosis. Acetylation of FOXO is associated with inflammatory cell activation and cellular apoptosis. Under resting conditions, inflammation-related genes are controlled by SIRT1 deacetylase. However, when NF-κB and FOXO are acetylated by CBP/p300, transcription of proinflammatory and apoptotic genes are initiated.