Table 1.
Mammalian SIRTs family: cellular functions and polyphenol effects
| Sirtuin | Intracellular Location |
Substrate | Function | Polyphenol effect |
Ref. |
|---|---|---|---|---|---|
| SIRT1 | Nucleus and cytoplasm |
NF-κB, p53, FOXO |
Cell survival, differentiation, inflammation, and metabolism |
Increase by resveratrol and quercetin |
[12–14, 16, 39, 224] |
| SIRT2 | Cytoplasm | α-tublin, Histone H4 |
Cell cycle | Activation by resveratrol |
[225] |
| SIRT3 | Nucleus and mitochondria |
Acetyl-CoA synthetase |
Metabolism | Increase by kaempferol |
[226] |
| SIRT4 | Mitochondria | ADP ribosyl transferase |
Metabolism | Not known | [227] |
| SIRT5 | Mitochondria | Mitochondrial protein |
Mitochondrial function |
Not known | [228] |
| SIRT6 | Nucleus | ADP-ribosyl transferase and Histone H3 |
DNA repair | Not known | [229] |
| SIRT7 | Nucleus | RNA polymerase I |
rRNA transcription | Increase by resveratrol |
[230] |