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. Author manuscript; available in PMC: 2011 Oct 15.
Published in final edited form as: Free Radic Biol Med. 2010 Jul 16;49(7):1212–1220. doi: 10.1016/j.freeradbiomed.2010.07.007

Fig. 6.

Fig. 6

Caffeine dose-dependently reduces endoplasmic reticulum (ER) stress induced by cholesterol-enriched diet in rabbit hippocampus. Representative Western blots (a) and densitometric analysis (b) showing increased levels of the ER-resident proteins calreticulin, grp78 and grp94 and of the ER stress marker protein gadd153. Caffeine administered at 30 mg/day of caffeine/day in drinking water decreased the cholesterol-induced increase in calreticulin, grp78, grpP94, and gadd153 levels. At 0.5 mg/day, caffeine only reduces grp78 and calreticulin levels. *p<0.05, **p<0.01 versus controls, #p<0.05, # #p<0.01 versus rabbits fed with 2% cholesterol-enriched diet.