HSV1716 |
17 |
Both γ134.5 gene copies deleted |
Phase 1 dose escalation, safety |
closed |
[21]. |
Phase 1b, single dose, assess intratumoral virus replication |
closed |
37] |
Phase Ib, safety of resection cavity administration |
closed |
[38] |
Phase III |
ongoing |
nexxusscotland.com website |
G207 |
F |
Both γ134.5 gene copies deleted, lacZ gene inserted into UL39 gene |
Phase 1 dose escalation, safety |
closed |
[20] |
Phase Ib, two dose regimen, one intratumor, one into resection cavity |
closed |
[17] |
Phase Ib |
closed |
Markert et al., submitted |
M032 |
F/M002 |
Both γ134.5 gene copies deleted |
Phase I, safety and dose escalation |
pending |
[15] |
C134 |
F/C101 |
Both γ134.5 gene copies deleted, HCMV gene IRS1 introduced within UL3/UL intergenic region |
Phase I safety and dose escalation |
planning stages |
[16] |