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. Author manuscript; available in PMC: 2010 Aug 31.
Published in final edited form as: Anal Chem. 2008 Jun 18;80(15):5873–5883. doi: 10.1021/ac8003665

Figure 4.

Figure 4

A) The normalized total ion currents (TIC) from bovine serum albumin (BSA) solutions at concentrations of 15 nM, 150 nM and 1500 nM as functions of the ion accumulation time in the IFT. TIC dependence at high concentration exhibits saturation at ~ 4 ms accumulation time in the IFT, indicating the need for multiple ion gating events throughout 60 ms IMS separation. TIC curve at low concentration approximates with a linear function, implying that the IFT charge capacity has not been reached on the timescale of IMS separation. B) Flow control diagram of the automated dynamic multiplexing experiment with IMS-TOFMS. The optimum encoding sequence is selected based on the IMS-TOFMS pre-scan signal.