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. 2010 Jul 26;190(2):233–245. doi: 10.1083/jcb.201001129

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© 2010 Cai et al.

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Figure 5. — Deletion of PiaA suppresses the unregulated chemotactic responses caused by RasC^Q62L. (A and B) ACA activation and actin polymerization were measured in wild-type (WT) or piaA⁻ cells induced to express Flag-RasC or -RasC^Q62L. ACA data represent the range (mean ± standard error) of two independent experiments. The basal activities ranged from 15.2 pmol/min/mg protein for Flag-RasC/piaA⁻ and -RasC^Q62L/piaA⁻ cells to 17.9 pmol/min/mg protein for Flag-RasC/WT and 19.2 pmol/min/mg protein for Flag-RasC^Q62L/WT cells. For the actin polymerization assay, the data represent mean ± SD of three independent experiments. A.U., arbitrary unit. (C) The micropipette assay was performed in aca⁻ or piaA⁻ cells induced to express Flag-RasC or -RasC^Q62L.