Figure 2.

Physiologic and behavioral responses to oxotremorine in C57BL/6J and BALB/cByJ mice. Body temperature, salivation, tremor, and reactions to painful stimuli were assessed 30 min after intraperitoneal injection of vehicle (pyrogen-free saline) or 1 of 3 doses of OXO (0.1, 0.2, or 0.3 mg/kg; n = 8 per strain at each dose). Tremor was assessed as: 0, no tremor; 1, intermittent head and body tremor; or 2, nearly continuous whole-body tremor. Salivation was assessed as: 0, none; 1, mild; 2, moderate; or 3, severe. For all panels, data are presented as mean ± SEM (bars).