Table 1.
Responses at 30 min after injection of 0.1 mg.kg oxotremorine |
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Strain | Chrm2 genotypea | Startle amplitudeb | PPIc | Hypothermia (°C) | Tremord | Salivationd | Bradycardia (bpm)d |
BALB/cByJ | BALB/cByJ | high | impaired | −4.4 ± 0.4 | 1.5 ± 0.2 | 1.5 ± 0.2 | −98 ± 22 |
C57BL/6J | C57BL/6J | low | normal | −4.0 ± 0.6 | 1.8 ± 0.2 | 1.2 ± 0.3 | −151 ± 39 |
CXB2 | C57BL/6J | not tested | not tested | −6.3 ± 0.5 | 1.8 ± 0.2 | 1.8 ± 0.2 | −86 ± 69 |
CXB3 | BALB/cByJ | low | impaired | −5.1 ± 0.6 | 2.0 ± 04 | 0.8 ± 0.2 | −190 ± 22 |
CXB5 | BALB/cByJ | not tested | not tested | −3.7 ± 0.6 | 2.0 ± 0.3 | 1,4 ± 0.4 | −157 ± 21 |
CXB6 | BALB/cByJ | high | normal | −4.5 ± 0.4 | 1.9 ± 0.1 | 1.3 ± 0.2 | −221 ± 44 |
CXB9 | BALB/cByJ | low | impaired | −6.5 ± 0.5 | 0.7 ± 0.2 | 0.6 ± 0.2 | −38 ± 23 |
CXB12 | C57BL/6J | high | impaired | −4.9 ± 0.7 | 1.8 ± 0.2 | 0.3 ± 0.2 | −81 ± 15 |