Fig. 3.

Cartoon representation of a homology model of NBD1 obtained using SWISS-MODEL server (Kiefer et al. 2009) and refined by energy minimization with the NAMD Molecular Dynamics Simulator (Phillips et al. 2005). The crystal structure of the ABC transporter ATP-binding protein from Thermotoga maritima (Protein data bank ID 1VPL, 33.3% sequence identity) was used as a template (Cideciyan et al. 2009). The RecA-like subdomain is yellow; the helical domain is pink. Walker A, Walker B and ABC signature motifs are red, blue and green, respectively. Single-residue motifs are shown as sticks. The figure was prepared with Pymol (http://pymol.sourceforge.net/)