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Study I (overexpression): representative en face Sudan IV-stained aortas (A). Quantitated lesion area (B) and lesion number (C) in aortas from apolipoprotein E knockout (ApoE KO; gray bars) and ApoE KO expressing human PAPP-A transgene (ApoE KO/PAPP-A Tg; black bars) mice after 10 wk on high-fat diet are shown. Results are means ± SE of n = 7–13 mice per group. *Significantly different from ApoE KO, P < 0.001.
