Table 1.
hPAPP-A expression in aortic smooth muscle cell cultures from WT and PAPP-ATg mice
| hPAPP-A mRNA | hPAPP-A | Proteolytic Activity | |
|---|---|---|---|
| WT | 0 | 0 | Low |
| Tg-3 | 2,110 ± 8 | 14 ± 0.1 | High |
| Tg-4 | 1,790 ± 146 | 22 ± 1.1 | High |
| Tg-4′ | 1,970 ± 392 | 6 ± 0.3 | High |
| Tg-5 | 98 ± 7 | 2 ± 1.5 | Medium |
| Tg-6′ | 7,080 ± 620 | 20 ± 0.3 | High |
| Tg-7 | ND | 1 ± 0.6 | Medium |
Values are means ± SE. Human pregnancy-associated plasma protein-A (hPAPP-A) mRNA are copies per nanogram mRNA. hPAPP-A is milli international units per 100,000 cells. Proteolytic activity is cell-free inhibitory IGF binding protein (IGFBP-4) proteolysis; see materials and methods. WT, wild-type; Tg, transgene; ND, not determined.