Fig. 1.
Trangenic (TG) myocyte (B) viability was significantly reduced compared with wild-type (WT) myocytes (A), and isoproterenol (ISO) treatment enhanced myocyte death in both groups. Nifedipine (NIF) increased survival of both WT and TG myocytes. ISO + NIF treatment increased myocyte viability compared with NIF alone in WT and initially in TG myocytes. Values are means ± SE; N = 7. C: representative images of WT myocytes at 12 h. *Significant difference vs. control (CON). #Significant difference, ISO + NIF vs. NIF. D: representative images of TG myocytes at 12 h. ISO is a nonselective β-adrenergic receptor (AR) agonist; NIF is an L-type Ca2+ channel (LTCC) antagonist.