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Effects of drugs modulating Ca2+ handlings on myocyte viability, with or without ISO treatment. A: WT myocyte viability at 12 h. B: TG myocyte viability at 12 h. Values are means ± SE; N = 6. *P < 0.05 vs. WT CON; #P < 0.05 vs. TG CON. Thapsigargin, a sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) inhibitor; KB-R7943, a Na+/Ca2+ exchanger (NCX) inhibitor; BAPTA-AM, an intracellular Ca2+ chelator; KN-93, a Ca2+/calmodulin-dependent kinase II (CaMKII) inhibitor.
