Fig. 7.
Myocyte contractility: [Ca2+]i transients after treatments was increased by β1-AR activation, but not by β2-AR activation. A and B: WT myocyte fractional shortening and [Ca2+]i transients, respectively, before and after β1-AR agonist DOB treatment. C: [Ca2+]i transient kinetics before and after DOB treatment. D and E: comparison of WT myocyte fractional shortening and [Ca2+]i transients, respectively, before and after β2-AR agonist ZIN treatment. F: [Ca2+]i transient kinetics before and after ZIN treatment. G and H: β1-AR antagonist CGP blunted ISO-induced increase of myocyte contractility in WT and TG mice, respectively. Values are means ± SE. *P < 0.05 vs. basal. #P < 0.05 vs. ISO.