Table 1.

Parameters and maximum gain of baroreflex control of heart rate before and after the AT₁ receptor antagonist candesartan in control and Beta sheep

	Control	Control Post-CV-11974	Beta	Beta Post-CV-11974
n	5	5	6	6
P1, beats/min	121.4 ± 9	104.7 ± 16	125.5 ± 13	101.1 ± 17
P2, beats·min−1·mmHg−1	0.12 ± 0.013	0.18 ± 0.036	0.065 ± 0.01*	0.13 ± 0.02†
P3, mmHg	84 ± 10	80 ± 5	107 ± 7*	90 ± 5†
P4, beats/min	51 ± 7	52 ± 9	55 ± 7	64 ± 7
Gmax, beats·min−1·mmHg−1	−3.8 ± 0.2	−4.3 ± 0.3	−1.9 ± 0.3*	−2.9 ± 0.4†

Values are means ± SE; n, no. of sheep for each condition. Post-CV-11974, after candesartan; Beta, betamethasone; P₁, range of heart rate; P₂, slope coefficient; P₃, mean arterial pressure at midrange; P₄, minimum heart rate; G_max, maximum gain of heart rate.

^*P < 0.05 vs. control.

^†P < 0.05 vs. Beta-exposed pre-candesartan.